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Darwin, circa 1850, formulated the Evolutionary Theory
Mendel, circa 1850, discovered the genes
Hugo Marie de Vries, near 1900, showed the existence of mutation and recombination
Electrophoresis allowed to prove (1930-1950) that there was enzymatic polymorphism
DNA sequencing allowed to prove recently that DNA was polymorphic
More than 99% of the genome is monomorphic